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姓名:张贝贝 导师类型:硕士生导师 职称:讲师 招生方向:微生物学专业/生物与医药专业 研究方向:I型单纯疱疹病毒(HSV-1)与宿主相互作用机制的解析,及抗病毒药物筛选 联系电话:17773759054 信箱:zhangbeibei2022@xju.edu.cn
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个人经历
教育经历:
(1) 2017-09 至 2021-12, 西北农林科技大学, 预防兽医学, 博士
(2) 2014-09 至 2017-06, 新疆大学, 生物化学与分子生物学, 硕士
(3) 2010-09 至 2014-06, 新疆大学, 生物技术, 学士
研究内容
以HSV-1为研究对象,针对病毒感染过程中宿主响应模式开展分子机制的解析,并利用潜在抗病毒药物进行体内抗病毒研究。
科研项目
1. 自治区青年科学基金,2023.01-2025.12,主持。
2. 天池英才计划(青年博士),2023.02-2026.02,主持。
代表性研究成果
1. Zhang B, Ding JT, Ma ZH. 2023. ICP4 Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells. Viruses. 15: 1457-1473.
2. Zhang B, Li S, Ding J, Guo J, Ma Z. 2024. Rap1b: A cytoskeletal regulator Advantageous to viral infection. iScience. 24;27(10):111023-1110136.
3. Zhang B, Fan J, Luo YH, Lv H, Zhao Q, Fan MN, Duan H, Liu BY, Nan YC, Sun YN, Zhou E-M. 2021. Development of a competitive ELISA for detecting antibodies against genotype 1 hepatitis E virus. Applied Microbiology and Biotechnology. 105(21-22):8505-8516.
4. Zhang, Fan MN, Fan J, Luo YH, Wang J, Wang YJ, Liu BY, Sun YN, Zhao Q, Hiscox JA, Nan YC, Zhou E-M. 2021. Avian hepatitis E virus ORF2 protein interacts with Rap1b to induce cytoskeleton rearrangement that facilitates virus internalization. Microbiology Spectrum. 2022, 10(1):e0226521.
5. Zhang B, Qu G, Nan Yuchen, Zhou E-M. 2021. Ovarian oxidative stress induced follicle depletion after zona pellucida 3 (ZP3) vaccination is associated with subfertility in BALB/c mice. Frontiers in Veterinary Science. 9:3389-3399.
6. Zhang B, Mao HY, Zhu HJ, Guo JX, Zhou Paul, Ma ZH, 2023. Response to HIV-1 gp160-carrying recombinant virus HSV-1 and HIV-1 VLP combined vaccine in BALB/c mice. Frontiers in Microbiology. 14: 1136664-11366674.