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86AD

    名:范仲雄

职称/职务:副教授

   业:高分子化学与物理

研究方向:功能性纳米材料的理性设计

招生方向:生物化学与分子生物学(学术型硕士研究生);制药工程(专业型硕士研究生)

   箱:fanzhongxiong@xju.edu.cn




个人经历。。。。               。。。。。。。。。。。。。。。。。。。。。。。。

教育经历

201809-202206月:厦门大学,博士。


讲授课程

本科生:《药学概论》、《药剂学》、《制药工程伦理学》、《生物工程设备》、《工厂设计与CAD》、《纳米科学与纳米技术》

研究生:《高级生物化学》、《现代微生物学研究技术》、《高等药剂学》、《药物代谢》

科研项目

1. 国家自然科学基金项目,2026/1-2029/12,在研,主持。

2. 新疆维吾尔自治区重点研发专项,2023/12-2026/12,在研,首席。

3. 2024年科普中国高校行项目(第二批),2024/8-2025/4,已结题,主持。

4. 2022年度自治区天池英才引进计划-青年博士项目2023/01-2026/1,在研,主持。

5. 新疆维吾尔自治区重点研发专项,2024/12-2027/12,在研,主持。

6. 新疆维吾尔自治区青年科学基金,2022/12-2025/12,在研,主持。

7. 新疆维吾尔自治区高校基本科研业务费科研项目-培育类项目2023/6-2026/6,在研,主持。

8. 新疆维吾尔自治区重点实验室开放课题,2023/8-2025/12,在研,主持。

9. 新疆中药制剂循证与转化重点实验室开放课题2025/1-2027/12,在研,主持。

10. 横向课题2项,在研,主持。

奖励情况

1. 2024年获自治区第一届博士后创新创业大赛优胜奖(负责人)

2. 2024年指导本科生参与生命科学竞赛获全国等奖和自治区二等奖

3. 2023年指导本科生生命科学竞赛全国二等奖和自治区一等奖

4. 2023年指导本科生获批国家级大学生创新训练计划项目

5. 2024年指导本科生获批国家级大学生创新训练计划项目

6. 2022年获得厦门大学优秀毕业生荣誉称号

7. 2022年获得厦门大学本栋奖学金

8. 2020年、2021年、2022年获得厦门大学校级“优秀三好学生”荣誉称号

9. 2021年获得厦门大学材料学院优秀共产党员荣誉称号

10. 2019年获得厦门大学中国航天科技集团公司CASC公益奖学金

11. 2016年获得硕士研究生国家奖学金

12. 2015年获得新疆维吾尔自治区学位委员会优秀论文奖

社会工作

1. 厦门大学新疆校友会第三届理事会常务理事、副会长

2. Exploration》和《国际生物医学工程杂志》编委

3. 教育部学位论文评审专家

4. 中国中医药信息学会常务理事

5. 中国生物物理学会纳米生物学分会委员

6. 中国心血管药理学专业委员会第三届青年委员会委员

7. 中国药理学会神经精神药理学专业委员会第二届青年委员会委员

8. 中国卒中学会第三届委员会委员

9. 中国卒中学会新药研发与评价分会第三届青年委员会委员

10. 中国实验动物学会屏障医学专业委员会学术委员会委员

11. 新疆佳音医院学术委员会委员

12. 审稿专业期刊20余本


代表性研究成果

已在Adv. Funct. Mater.Chem. Eng. JBiomaterials.Anal. Chem.J. Nanobiotechnol.Nano Res.Mater. Today Bio.等国际高水平期刊发表SCI论文50余篇,H-index 30,授权国家专利3项。审稿高水平专业期刊20余本,作为执行主席主办国际会议1次、协助组织全国性学术会议2次,重要学术会议做大会报告10次。在新疆地区组织科普宣讲/义诊10/次。已发表主要学术论文如下:

1. Xia, G.‡; Fan, Z.*; Wang, Q.; Li, J.; Zhang, Y.; Adila, A.; Su, Q.; Li, Ying.; Hou, Z.*; Li, J.* Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy. J. Nanobiotechnol., 2025, 23(1): 167JCR 1. 当年影响因子:12.6

2. Tan, X.; Li, Y.; Jin, H.; Zhou, Y.; Li, W.; Zhao, Y.; Hai, J.; Li, J.; Fan, Z.*; Yang, L. * Metformin-induced precise targeted inhibition of ischemic neuronal death by a programable endogenous ROS-responsive nanoprodrug. Chem. Eng. J, 2025, 512: 162106.JCR 1. 当年影响因子:13.4

3. Gao, F.; Lin, W.; Zhao, T.; Zhang, J.; Pei, D.; Di, D.; Fan, Z.*; Yang, L.; Hai, J. Visual whole-process monitoring dynamic phase separation of autophagic lysosomes in Alzheimer’s Disease by a lysosome-targeted pH-activated fluorescence probe. Anal. Chem., 2025,  https://doi.org/10.1021/acs.analchem.5c02994JCR 1. 当年影响因子:6.7

4. Chen, K.; Zhang, Y.; Fan, Z.*; Zhu, J.; Xu, Q.; Xu, J*. Valence electronic modulation induced by reinforcing interfacial coupling for expediting sulfur redox in Li-S batteries. Adv. Funct. Mater. 2025, 2500574. JCR 1. 当年影响因子:19.0

5. Zhang, J.; Jing, Q.; Yuan, L.; Zhou, X.; Di, D.; Li, J., Pei, D.; Fan, Z.*; Hai, J.* NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD. Mater. Today Bio., 2025, 31: 101540-101540.JCR 1 .当年影响因子:10.6

6. Fu, X.;  Zhao, L.;  Yin, W.;  Hou, S.;  Liu, H.;  Kou, L.;  Fan, Z.*; Zhang, D.*, Redox-responsive self-targeting carrier-free nanotherapeutic agent with ROS storm for enhancing tumor oxidative stress. Colloids Surf. B., 2025, 256: 115069. JCR 1 . 当年影响因子5.6

7. Jing, Q.; Zhang, J.; Yuan, L.; Zhang, H.; Lin, W.; Pei, D.; Di, D.; Yang, L.; Fan, Z.*; Hai, J.* Copper-based hollow mesoporous nanogenerator with reactive oxygen species and reactive nitrogen species storm generation for self-augmented immunogenic cell death-mediated triple-negative breast cancer immunotherapy. J. Colloid Interface Sci., 2025, 688, 688-702JCR 1. 当年影响因子:9.4

8. Fan, Z.‡; Jin, H.‡; Tan, X.‡; Li, Y.‡; Shi, D.; Wang, Q.; Meng, J.; Li, W.; Chen, C.; Peng, L.; Hou, Z.; Li, J.*; Jin, X.*; Yang, L.* ROS-responsive hierarchical targeting vehicle-free nanodrugs for three-pronged Parkinson's disease therapy. Chem. Eng. J, 2023, 466: 143245.JCR 1. 当年影响因子:16.744

9. Fan, Z.‡; Ren, T.‡; Wang, Y.‡; Jin, H.; Shi, D.; Tan, X.; Ge, D.; Hou, Z.; Jin. X.; Yang. L.* Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβ clearance. Biomaterials., 2022, 283: 121452.JCR 1. 当年影响因子: 15.304

10. Fan, Z.‡; Xia, G.‡; Zhu, F.‡; Yang, N.; Ma, A.; Shi, Y.; Jiang, Z.; Zhou, X.; Hou, Z.* Ruthenium-quercetin coordinated nanotherapeutics with macrophage polarization regulation to rapidly promote bacterial-infected wound healing. Mater. Today Bio., 2025, 31: 101540-101540.JCR 1 . 当年影响因子:10.6

11. Liu. H.; Zhuo. R.; Zou. C.; Xu. S.; Cai. X.; Ge. Y.; Liu. G.; Wu. C.; Dai. C.; Li. J.; Xu. S.; Fan, Z.*; Yang, L.; Li, Y.* RVG-peptide-camouflaged iron-coordinated engineered polydopamine nanoenzyme with ROS scavenging and inhibiting inflammatory response for ischemic stroke therapy. Int. J. Biol. Macromol., 2024, 282: 136778. JCR 1. 当年影响因子:7.7

12. Fan, Z.;  Zhu, F.;  Wu, F.;  Yang, N.;  Ma, A.;  Bai, W.;  Jiang, Z.;  Hou, Z.*; Zhou, X.* Self-targeting carrier-free coordination nanotherapeutics for tumor microenvironment modulation and enhanced chemo-dynamic oncotherapy. Colloids Surf. B., 2025, 256: 114980.JCR 1 . 当年影响因子:5.6

13. Fan, Z.;  Ma, A.;  Zhu, F.;  Meng, J.;  Yang, N.;  Ma, W.;  Jiang, Z.;  Hou, Z.*; Zhou, X.* Carrier-free metal-organic nanodrugs via coordination-driven self-assembly for synergistic anti-angiogenesis and oxidative-stress oncotherapy. Nano Res., 2025, 18: 94908073. JCR 1 . 当年影响因子:5.6

14. Zhang, X.; Zhang, K.; Liu, K.; Yu, S.; Fu, X.; Yuan, Q.; Zhu, C.; Lin, D.*; Fan, Z.* A novel supramolecular nanodrugs for improving the cognitive function of schizophrenia by protecting active lactone of arecoline. Biomed. Pharmacother., 2025, 183: 117845-117845.JCR 1 . IF7.5

15. Fan, Z.; Jiang, B.; Zhu, Q.; Xiang, S.; Tu, L.; Yang, Y.; Zhao, Q.; Huang, D.; Han, J.; Su, G.; Ge, D.; Hou, Z. Tumor-specific endogenous FeII-activated, MRI-guided self-targeting gadolinium-coordinated theranostic nanoplatforms for amplification of ROS and enhanced chemodynamic chemotherapy. ACS Appl. Mater. Interfaces., 2020, 12 (13): 14884-14904.JCR 1. 当年影响因子:10.383

16. Shi, D.; Wu, F.; Huang, L.; Li, Y.; Ke S.*; Li, J.*; Hou, Z.*; Fan, Z.* Bioengineered nanogenerator with sustainable reactive oxygen species storm for self-reinforcing sono-chemodynamic oncotherapy. J. Colloid Interface Sci. 2023, 603: 70-84.JCR 1. 当年影响因子:9.965

17. Fan, Z.; Shi, D.; Zuo, W.; Feng. J.; Ge. D.; Su. G.;* Yang. L.;* Hou. Z.* Trojan-horse diameter-reducible nanotheranostics for macroscopic/microscopic imaging-monitored chemo-antiangiogentic therapy. ACS Appl. Mater. Interfaces., 2022, 14 (4): 5033-5052.JCR 1. 当年影响因子:10.383

18. Wang, Q.; Meng, J.; Huang, L.; Wu, F.; Yi, X.; Su, G.; Li, Y.*; Hou, Z.*; Fan, Z.* Platinum-coordinated engineered nanoreactors with O2 self-amplificationand on-demand cascade chemo-drug synthesis for self-reinforcing hypoxic oncotherapy. ACS Appl. Mater. Interfaces., 2023, 15 (14): 17495-17506.JCR 1. 当年影响因子:10.383

19. Fan, Z.; Wang, Y.; Xiang, S.; Zuo, W.; Huang, D.; Jiang, B.; Sun, H.; Yin, W.;* Xie, L.;* Hou, Z.* Dual-self-recognizing, stimulus-responsive and carrier-free methotrexate–mannose conjugate nanoparticles with highly synergistic chemotherapeutic effects. J. Mater. Chem. B., 2020, 8 (9): 1922-1934.JCR 1. 当年影响因子:7.571

20. Huang, L.; Wu, F.; Wang, Q.; Meng, J.; Feng, J.; Su, G.*; Yi, X.; Li, Y.*; Li, J.-Y.*; Hou, Z.*; Fan, Z.* TME-triggered copper-coordinated engineered programmable nanogenerators for on-demand cascade-amplifying oxidative stress. J. Mater. Chem. B., 2023, 11 (16): 3679-3692JCR 1. 当年影响因子:7.571

21. Yang, Q., Ye, W.; Luo, D.; Xing, J.; Xiao, Q.; Wu, H.; Yao, Y.; Wang, G.; Yang, L.; Guo, D.; Wang, K.; He, Y.; Ye, X.; Zhang, J.; Jing, Z.; Fan, Z.*; Wen, X.; Mao, J.; Chen, X.; Zhao, Q.* Neuroprotective effects of anti-TRAIL-ICG nanoagent and its multimodal imaging evaluation in cerebral ischemia-reperfusion injury. Mater. Today Bio., 2024, 26: 101094JCR 1. 当年影响因子:8.2

22. Zhuo, R.; Song, Z.; Wang, Y.; Zhu, M.;  Liu, F.;  Lin, P.;  Rao, R.;  Zhou, Y.;  Zhao, Y.;  Fan, Z.*;  Cui, L.;  Liu, H.;  Li, J.;  Li, Y.;  Guo, H.;  Cai, C. F.; Yang, L.*, Oleoylethanolamide ameliorates motor dysfunction through PPARα-mediates oligodendrocyte differentiation and white matter integrity after ischemic stroke. Phytotherapy Research, 2023, 37: 5341-5353.JCR 1. 当年影响因子:7.5

23. Song, M.; Aipire, A.; Dilxat, E.; Li, J.; Xia, G.; Jiang, Z.; Fan, Z.*; Li, J.*, Research progress of polysaccharide-gold nanocomplexes in drug delivery. Pharmaceutics, 2024, 16: 88.JCR 1. 当年影响因子:5.400

24. Yu, S.; Xia, G.; Yang, N.; Yuan, L.; Li, J.; Wang, Q.; Li, D.; Ding, L.; Fan, Z.*; Li, J.* Noble metal nanoparticle-based photothermal therapy: development and application in effective cancer therapy. Int. J. Mol. Sci. 2024, 25(11): 5632.( JCR 1.当年影响因子:5.6

25. Yang, N.; Li, J.; Yu, S.; Xia, G.; Li, D.; Yuan, L.; Wang, Q.; Ding, L.; Fan, Z.*; Li, J.* , Application of nanomaterial-based sonodynamic therapy in tumor therapy. Pharmaceutics, 2024, 16: 603.JCR 1. 当年影响因子:5.4

26. Wang, Q.; Xia, G.; Li, J.; Yuan, L.; Yu, S.; Li, D.; Yang, N.; Fan, Z.*; Li, J. Multifunctional nanoplatform for NIR-II imaging-guided synergistic oncotherapy. Int. J. Mol. Sci. 2023, 24: 16949.JCR 1 区;当年影响因子:5.6

27. Chen, K.; Lin, Z; Zhang, G.; Zheng, J.; Fan, Z.*; Xiao, L.; Xu, Q.; Xu, J.* Efficient host materials for lithium-sulfur batteries: ultrafine CoP nanoparticles in black phosphorus-carbon composite. ChemSusChem, 2024, 17 (14): e202400339.JCR 1. 当年影响因子:8.4

28. Li, Y.; Wu, C.; Yang, R.; Tang, J.; Li, Z.; Yi, X.; Fan, Z. Application and development of cell membrane functionalized biomimetic nanoparticles in the treatment of acute ischemic stroke. Int. J. Mol. Sci., 2024, 25: 8539.JCR 1 区;当年影响因子:5.6

29. Fan, Z.*; Xia, G.; Wang, Q.; Chen, S.; Li, J.; Hou, Z.; Jiang, Z.; Feng, J*. Endogenous Fe2+-triggered self-targeting nanomicelles for self-amplifying intracellular oxidative stress. Anim Models Exp Med., 2024, 8 (2): 307-321.JCR 2 区;当年影响因子:3.8

30. Li, W.; Zhang, H.; Xu, J.; Maimaitijiang, A.; Su, Z.; Fan, Z.; Li, J. The biological roles of ZKSCAN3 (ZNF306) in the hallmarks of cancer: from mechanisms to therapeutics. Int. J. Mol. Sci., 2024, 25: 11532.JCR 1 区;当年影响因子:5.6

31. Fan, Z.; Jiang, B.; Shi, D.; Yang, L.; Yin, W.; Zheng, K.; Zhang, X.; Xin, C.; Su, G.*; Hou, Z.*, Selective antitumor activity of drug-free TPGS nanomicelles with ROS-induced mitochondrial cell death. Int. J. Pharm., 2021, 594: 120184.JCR 1. 当年影响因子:6.510

32. Maimaitijiang, A.; He, D.; Li, D.; Li, W.; Su, Z.; Fan, Z.; Li, J. Progress in research of nanotherapeutics for overcoming multidrug resistance in cancer. Int. J. Mol. Sci., 2024, 25: 9973.JCR 1区;当年影响因子:5.6

33. Zhang, X.; Zhu, X.; He, Y.; Zhang, Y.*; Huang, S.; Yi, X.; Li, Y.*; Hou, Z.*; Fan, Z.* Biomimetic dual-responsive bioengineered nanotheranostics for intracellular cascade-synthesizing chemo-drugs and efficient oncotherapy. J. Mater. Chem. B., 2023, 11 (1): 119-130.JCR 1.当年影响因子:7.571

34. Fu, X.; Yin, W.; Shi, D.; Yang, Y.; He, S.; Hai, J.; Hou, Z.; Fan, Z.*; Zhang, D.*, Shuttle-shape carrier-free platinum-coordinated nanoreactors with O2 self-supply and ROS augment for enhanced phototherapy of hypoxic tumor. ACS Appl. Mater. Interfaces., 2021, 13 (28), 32690-32702.JCR 1. 当年影响因子:10.383

35. Shi, D.; Zhuang, J.; Fan, Z.*; Zhao, H.; Zhang, X.; Su, G.; Xie, L.*; Ge, D.*; Hou, Z.*, Self-targeting nanotherapy based on functionalized graphene oxide for synergistic thermochemotherapy. J. Colloid Interface Sci., 2021, 603: 70-84.Inside cover, JCR 1. 当年影响因子:9.965

36. Guo, F.; Shang, J.; Zhao, H.; Lai, K.; Li, Y.; Fan, Z.*; Hou, Z.*; Su, G.*, Cube-shaped theranostic paclitaxel prodrug nanocrystals with surface functionalization of SPC and MPEG-DSPE for imaging and chemotherapy. Colloids Surf. B., 2017, 160: 649-660.JCR 2. 当年影响因子:5.999

37. Yin, W.; Fu, X.; Chang, W.; Han, L.; Meng, J.; Cao, A.; Meng, J.; Ren, X.; Fan, Z.*; Zhou, S.*, Anti-ovarian cancer mechanism of esculetin: inducing G0/G1 arrest and apoptosis via JAK2/STAT3 signaling pathway, J. Pharm. Pharmacol., 2022, http://dx.doi.org/10.1093/jpp/rgac083.JCR 2. 当年影响因子:4.810


已授权专利

1. 一种甲氨蝶呤金属配位聚合物及其制备方法和应用,专利号:201910970581.4

2. 一种多西紫杉醇复合缓释剂及其制备方法,专利号:ZL201711461126.9

3. 一种可分离式微针系统及模具,专利号:202420024074.8


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