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姓名：许岳慷 职称：教授、博士生导师 研究方向：炎症免疫与信号传导 招生方向：生物化学与分子生物学
Email：3362994022@qq.com |
◆主要学习工作经历
1985年毕业于安徽医科大学临床医学系，获医学学士；1987年毕业于安徽师范大学英语系，获文学学士；2004年毕业于澳大利亚墨尔本大学医学生物系，获哲学博士学位。先后在安徽医科大学、安徽省医学遗传中心任助教、助研等职。于1998年赴海外定居、读博,并在当地Walter+Eliza Hall Institute医学研究所从事医学免疫学的基础与临床研究工作。现任新疆大学特聘教授、博士生导师、免疫学科带头人。
◆主要社会兼职
● 安徽省免疫学会常务理事
● 安徽省细胞生物学会常务理事
● Frontiers in Immunology, Associated Editor, T Cell Biology (副主编）
◆主要研究内容
● 免疫细胞的信号传导：当外界病原微生物如新冠病毒侵入机体时，免疫细胞首先做出反应。本实验室主要研究免疫细胞在受到炎性刺激后，胞内信号通路中哪些分子发生了变化，这些变化最终如何改变免疫细胞功能和行为，以及根据这些变化找到并合成该分子的类似物或拮抗剂以控制炎性信号及“细胞因子风暴”的发展，从而达到临床治疗的目的。
● 炎性树突状细胞的发育和功能：树突状细胞在免疫反应中起着支配和主导作用。不同的生长因子和生长环境控制产生不同的树突状细胞。本实验室主要研究在炎症条件下树突状细胞的发育过程中哪些因素通过什么方式控制产生了什么类型的树突状细胞，这些树突状细胞功能上有什么区别，能主导着什么样的免疫反应，以及我们能否利用这些因素在体外定向生产这种树突状细胞回输体内干预免疫反应。
● 血管组织区域免疫：与经典的外周淋巴组织不同，心血管组织被纳入的是循环系统而非免疫器官。但该组织却孕育许多与免疫紊乱有关的急、慢性心血管炎症，可继发为冠心病、脑梗死等人类重大疾病，提示该组织区域具有免疫潜能。然而，由于血管组织免疫细胞较少、提取困难，致使该组织区域免疫特性鲜为人知，阻碍了对炎性血管疾病机制的了解和治疗。本实验室主要研究血管组织区域驻留免疫细胞与经典淋巴组织中免疫细胞不同的免疫特性，从而揭示造成血管组织炎症的本质。
● 抗体研发：本实验室运用新一代分子生物学手段对与疾病发生发展密切相关的蛋白抗原进行克隆，纯化并制备单克隆抗体。然后通过体外模拟体内亲和力成熟的新技术挑选出高亲和力抗体，再利用先进的胶体金和纳米方法制备高灵敏的快速检测试剂盒，应用于临床上重大疾病的诊断和治疗。
◆主要研究课题
● 国家自然科学基金重大研究计划项目、血管组织DC的区域免疫特性及抑炎机制、91742101、国家基金委、主持。
● 安徽省外国专家项目、重大感染性疾病中树突状细胞免疫调控机制的研究、S202234018, 安徽省科学技术厅、主持。
● 安徽省对外科学技术合作项目、炎症条件下树突状细胞发育和功能的分子机制研究、 1604b0602017、安徽省科技厅、主持。
● 安徽省自然基金面上项目、胱抑素 C 调控在血管内膜损伤机制中的研究、1608085MH160、安徽省自然科学基金委员会、主持。
● 澳大利亚国立卫生医学研究委员会项目基金、 Regulation of Cardiovascular Disease-Associated Protease Inhibitor Cystatin C for Therapeutic Application、1006428、主持。
● 澳大利亚国立卫生医学研究委员会 Peter Doherty 基金、Improving Anti-Tumor Therapy by Genetically Modifying CD4+ T cells、400426、主持。
● 美国 Susan Komen 基金、Genetic Modification of Multiple Immune System Cells for Breast Cancer Therapy、PDF39606、主持。
◆主要研究成果
一、代表性论文及论著：
l Zhang W, Cai Z, Ma D, Liu M, Wang J, Sun L, Lew AM, Xu Y*. Local adaptive immunity in atherosclerosis with T cell activation by aortic dendritic cells accelerates pathogenesis. iScience. Oct 10;27(11):111144. (2024)
l Wang J, Liu M, Cai Z, Zahid R, Zhang W, Ma D, Li D, Liang Y, Zha L, Zhou Y, Wang L, Yang G, Zheng S, Xu Y*. Pathogenic epitope-specific monoclonal antibody-based immunoassay for accurate diagnosis and monitoring of tetranectin in sepsis. Int Immunopharmacol. 143(Pt 3):113473. (2024)
l Zahid R, Wang J, Cai Z, Ishtiaq A, Liu M, Ma D, Liang Y, Xu Y*. Single chain fragment variable, a new theranostic approach for cardiovascular diseases. Front Immunol. 15:1443290. (2024)
l Zhang W, Wang X, He X, Xu Y*. Editorial: Adaptive immunity in local tissues. Front Immunol. 14:1200663. (2023)
l Wang F, Liu M, Ma D, Cai Z, Liu L, Wang J, Zhang W, Zhao L, Zhai C, Xu Y*. Dendritic cell-expressed IDO alleviates atherosclerosis by expanding CD4+CD25+Foxp3+Tregs through IDO-Kyn-AHR axis. Int Immunopharmacol. 116:109758. (2023).
l Li M, Lu W, Meng Y, Zhang W, Wang F, Sun L, Xu Y*. Tetrahydroxy Stilbene Glucoside Alleviates Ischemi Stroke by Regulating Conformation-Dependent Intracellular Distribution of PKM2 for M2 Macrophage Polarization. J Agric Food Chem. 70(49):15449-15463. (2022).
l L Sun, W Zhang, L Zhao, Y Zhao, F Wang, Andrew M. Lew Xu Y*. Self- Tolerance of Vascular Tissues Is Broken Down by Vascular Dendritic Cells in Response to Systemic Inflammation to Initiate Regional Autoinflammation. Front Immunol. | doi: 10.3389/fimmu.2022.823853. (2022).
l Y Zhao, J Zhang, W Zhang, Xu Y*. A myriad of roles of dendritic cells in atherosclerosis. Clin Exp Immunol. 206(1):12-27. (2021)
l Wang F, Liang S, Hu J, Xu Y*. Aryl hydrocarbon receptor connects dysregulated immune cells to atherosclerosis. Immunol Lett. 228:55-63. (2020).
l Sun L, Zhang W, Zhao Y, Wang F, Liu S, Liu L, Zhao L, Lu W, Li M, Xu Y*. Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead. Front Immunol. 11:1456. (2020).
l Chen S, Liu L, Zhang W, Sun L, Wang F, Zhao Y, Liu S, Zhao L, Xu Y*. Suppressed Dendritic Cell Functions by Cystatin C Lead to Compromised Immunity in Vivo. Cell Immunol. 349:104049. (2020).
l Zhang W, Zi M, Sun L, Wang F, Chen S, Zhao Y, Liang S, Hu J, Liu S, Liu L, Zhan Y, Lew AM, Xu Y*. Cystatin C regulates MHC II-peptide presentation and Erk- dependent polarizing cytokine production by bone marrow-derived dendritic cells. Immunol Cell Biol. Sep 12. doi: 10.1111/imcb.12290. (2019).
l Sun L, Rautela J, Delconte RB, Souza-Fonseca-Guimaraes F, Carrington EM, Schenk RL, Herold MJ, Huntington ND, Lew AM, Xu Y*, Zhan Y*. GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function. Front Immunol. 9:1922. (2018).
l Zhang, W., Y Ding, L. Sun, Q. Hong, Y. Sun, L. Han, M. Zi, Y. Xu*, Bone marrow- derived inflammatory and steady state DCs are different in both functions and survival. Cell Immunol, 331,100-109 (2018).
l Chen. S, X. Li, W. Zhang, M. Zi, Y. Xu*, Inflammatory compound lipopolysaccharide promotes the survival of GM-CSF cultured dendritic cell via PI3 kinase-dependent upregulation of Bcl-x. Immunol Cell Biol, doi: 10.1111/imcb.12051. [Epub ahead of print] (2018).
l Xu Y*, Lindemann P, Vega-Ramos J, Zhang JG, Villadangos JA. Developmental Regulation of Synthesis and Dimerization of the Amyloidogenic Protease inhibitor Cystatin C in the Hematopoietic System. J Biol Chem. 289(14):9730-40. (2014).
l Xu Y*, Fairfax K, Light A, Huntington ND, Tarlinton DM. CD19 Differentially Regulates BCR Signalling through the Recruitment of PI3K. Autoimmunity. Jun 23:1-8. (2014).
l Xu WD. Pan HF, Ye DQ, and Xu Y*. Targeting IRF4 in autoimmune diseases. Autoimmun. Rev. 11:918. (2012).
l Xu Y*, Schnorrer P, Proietto A, Kowalski G, Febbraio MA, Acha-Orbea H, Dickins RA and Villadangos JA. Interleukin-10 Controls Cystatin C Synthesis and Blood Concentration in Response to Inflammation through Regulation of IRF-8 Expression. J. Immunol. 186:3666 (2011).
l Xu Y*, Zhan Y, Lew AM, Naik SH and Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J. Immunol 179(11):7577-84 (2007).
l Xu Y, Darcy PK, and Kershaw MH. Tumor-specific dendritic cells generated by genetic redirection of Toll-like receptor signaling against the tumor-associated antigen, erbB2. Cancer Gene Ther. 14(9):773-80 (2007).
l Huntington ND, Xu Y, Puthalakath H, Light A, Willis SN, Strasser A, Tarlinton DM. CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat. Immunol. 7(2):190-8. (2006).
l Xu Y, Harder KW, Huntington ND, Hibbs ML, and Tarlinton DM. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity. 22:9-18 (2005).
二、主要获奖情况：
l 2021安徽省科学技术合作
l ICB Publications of the Year Runner Up Awards, Australia
l International Travel Bursary from 4th Congress of the Federation of Immunology Societies of Asia-Oceania (FIMSA), Taipei, Taiwan.
l International Travel Award from Australian Society of Immunology.
l NHMRC Peter Doherty Fellowship, Australia.
l Susan Komen Postdoctoral Fellowship, Susan Komen Foundation, USA
